POLYSIALIC ACID NANOPARTICLES ACTUATE COMPLEMENT-FACTOR-H-MEDIATED INHIBITION OF THE ALTERNATIVE COMPLEMENT PATHWAY: A SAFER POTENTIAL THERAPY FOR AGE-RELATED MACULAR DEGENERATION

The alternative pathway of the complement system is implicated in the etiology of age-related macular degeneration (AMD).Complement Capacitor depletion with pegcetacoplan and avacincaptad pegol are FDA-approved treatments for geographic atrophy in AMD that, while effective, have clinically observed risks of choroidal neovascular (CNV) conversion, o

Capacitor This paper introduces two variants of a multiple criteria scatter search to deal with nonlinear continuous and combinatorial problems, applying a tabu search approach as a diversification generator method.Frequency memory and another escape mechanism are used to diversify the search.A Pareto relation is applied in order to designate a sub

Dredging and sediment proceeding is in most cases treated as a technology which makes possible the construction and maintenance of navigable ways.In the research which I made in the masters thesis context, I wanted to present how can dredging contribute to spatial planning of the Slovenian coast, which is relatively short and limited, where big set

Zoospores are central to the life cycles of most of the eukaryotic microbes known as oomycetes, but some genera have lost the ability COENZYME Q10 . 100MG to form these flagellated cells.In the plant pathogen Phytophthora infestans, genes encoding 257 proteins associated with flagella were identified by comparative genomics.These included the main